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Very poor/Substantial Metabolizers, CYP2D6 The formation in the active metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Around 7% of your populace has minimized action from the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme procedure. These people are “lousy metabolizers” of debrisoquine, dextromethorphan and tricyclic anti